Although Niles and Frasier are very much alike and are very close they have always been extremely critical of each other. Niles appears to be quite jealous of Frasier, seeing him as the more dominant, stronger brother.

The brothers Crane spends a lot of time at "Cafe Nervosa," where they engage in many of their discussions.

As a psychiatrist, Niles holds several self-help groups. Five of them are:

Healing With Humor support group

Multiple Personality Disorder seminar

Fear of Abandonment workshop

Sexual Addiction group

Fear of Intimacy group

Niles has long harboured an infatuated with his father, Martin's physiotherapist, Daphne, but, it took him many years to find the courage to declare his love to her.